Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain
Kyle Taing
Lawrence Chen
Han-Rong Weng
Department of Basic Sciences,California Northstate University College of Medicine,Elk Grove,CA,USA
摘要：Neuroinflammation plays a critical role in the pathological process of multiple neurological disorders and pathological pain conditions. GPR109A, a Gi protein-coupled receptor, has emerged as an important therapeutic target for controlling inflammation in various tissues and organs. In this review, we summarized current data about the role of GPR109A in neuroinflammation. Specifically, we focused on the pharmacological features of GPR109A and signaling pathways used by GPR109A to ameliorate neuroinflammation and symptoms in Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and pathological pain conditions.
机标关键词：diseasesemerginginflammationneurologicalpainregulationroles
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 763-768 )
英文信息