Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration
Sandeep Satapathy1
Mark R.Wilson2
1.Blavatnik Institute of Cell Biology,Harvard Medical School,Boston,MA,USA;The Broad Institute of MIT and Harvard,Cambridge,MA,USA2.Molecular Horizons and The School of Chemistry and Molecular Bioscience,University of Wollongong,Northfields Avenue,Wollongong,NSW,Australia;Illawarra Health and Medical Research Institute,Northfields Avenue,Wollongong,NSW,Australia
摘要：Protein quality control involves many processes that jointly act to regulate the expression, localization, turnover, and degradation of proteins, and has been highlighted in recent studies as critical to the differentiation of stem cells during regeneration. The roles of constitutively secreted extracellular chaperones in neuronal injury and disease are poorly understood. Extracellular chaperones are multifunctional proteins expressed by many cell types, including those of the nervous system, known to facilitate protein quality control processes. These molecules exert pleiotropic effects and have been implicated as playing important protective roles in a variety of stress conditions, including tissue damage, infections, and local tissue inflammation. This article aims to provide a critical review of what is currently known about the functions of extracellular chaperones in neuronal repair and regeneration and highlight future directions for this important research area. We review what is known of four constitutively secreted extracellular chaperones directly implicated in processes of neuronal damage and repair, including transthyretin, clusterin, α2-macroglobulin, and neuroserpin, and propose that investigation into the effects of these and other extracellular chaperones on neuronal repair and regeneration has the potential to yield valuable new therapies.
机标关键词：regenerationchaperonesconstitutivelyextracellularneuronalrepairrolessecreted
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 769-772 )
英文信息