Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury
Luigi Manni1
Giorgio Conti2
Antonio Chiaretti3
Marzia Soligo1
1.Institute of Translational Pharmacology,National Research Council of Italy(CNR),Rome,Italy2.Intensive Pediatric Therapy and Pediatric Trauma Center,Department of Emergency,Anesthesiological and Reanimation Sciences,Fondazione Policlinico Universitario A.Gemelli IRCCS,Rome,Italy3.Institute of Pediatrics,Department of Woman and Child Health, Fondazione Policlinico Universitario A.Gemelli IRCCS,Rome,Italy
摘要：Traumatic brain injury is one of the main causes of mortality and disability worldwide. Traumatic brain injury is characterized by a primary injury directly induced by the impact, which progresses into a secondary injury that leads to cellular and metabolic damages, starting in the first few hours and days after primary mechanical injury. To date, traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative therapies. Nerve growth factor is a neurotrophin targeting neuronal and non-neuronal cells, potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain injury. This potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been exploited. Indeed, molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain, with favorable kinetics, dynamics, and safety profile. In the first part of this review, we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor treatment. In the second part, we then exposed the experimental evidence relating to the action of nerve growth factor (both in vitro and in vivo, after administration routes other than intranasal) on some of these mechanisms. In the last part of the work, we, therefore, discussed the few manuscripts that analyze the effects of treatment with nerve growth factor, intranasally delivered to the brain parenchyma, on the outcomes of traumatic brain injury.
机标关键词：recoverygrowthbrainfactorinjuryintranasalnerveoutcomes
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 773-778 )
英文信息