Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events
Zhen-Xiao Ren1
Jing-Hui Xu1
Xing Cheng1
Gui-Xing Xu2
Hou-Qing Long1
1.Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology/Department of Spine Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China2.Department of Neurosurgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China
摘要：Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury, with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis. In the progression of this condition, the microvascular network is compressed and destroyed, resulting in ischemia and hypoxia. The main pathological changes are inflammation, damage to the blood spinal cord barriers, and cell apoptosis at the site of compression. Studies have confirmed that vascular regeneration and remodeling contribute to neural repair by promoting blood flow and the reconstruction of effective circulation to meet the nutrient and oxygen requirements for nerve repair. Surgical decompression is the most effective clinical treatment for this condition; however, in some patients, residual neurological dysfunction remains after decompression. Facilitating revascularization during compression and after decompression is therefore complementary to surgical treatment. In this review, we summarize the progress in research on chronic compressive spinal cord injury, covering both physiological and pathological changes after compression and decompression, and the regulatory mechanisms of vascular injury and repair.
机标关键词：cordpathchroniccompressiveeventsinjurymechanismsphysiological
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 790-796 )
英文信息