Nilotinib: from animal-based studies to clinical investigation in Alzheimer 's disease patients
Annalisa Nobili1
Marcello D'Amelio1
Maria Teresa Viscomi2
1.Department of Medicine and Surgery,University Campus Bio-Medico,Department of Experimental Neuroscience,IRCCS Santa Lucia Foundation, Rome,Italy2.Department of Life Science and Public Health Section of Histology and Embryology,Università Cattolica del Sacro Cuore,Fondazione Policlinico Universitario"A.Gemelli",IRCCS,Rome,Italy
摘要：Since their first description in the brains of patients suffering from Alzheimer's disease (AD), more than 100 years ago, extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles have been the principal focus of AD research. However, this focus has led to the failure of several long and promising clinical trials, and the efficacy of new Aβ-targeting drugs to slow down the disease progression is still controversial despite being successful in reducing the Aβ load.
机标关键词：alzheimernilotinibclinicalstudiesfromanimal-baseddiseaseinvestigation
论文发表日期：2023-04-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 803-804 )