Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases
Syed Aoun Mehmood Sherazi1
Asim Abbasi2
Abdullah Jamil3
Mohammad Uzair1
Ayesha Ikram4
Shanzay Qamar4
Adediji Ayomide Olamide5
Muhammad Arshad1
Peter J.Fried6
Milos Ljubisavljevic7
Ran Wang8
Shahid Bashir9
1.Department of Biological Sciences,Faculty of Basic&Applied Sciences,International Islamic University,Islamabad,Pakistan2.Department of Biological Sciences,University of Arkansas,Fayetteville,AR,USA3.Department of Pharmacology,Government College University,Faisalabad,Pakistan4.Department of Bioinformatiics and Biotechnology,Government College University,Faisalabad,Pakistan5.Department of Chemistry,Chulalongkorn University,,Thailand6.Department of Neurology,Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology,Beth Israel Deaconess Medical Center(KS 158),Harvard Medical School,Boston,MA,USA7.Department of Physiology,College of Medicine and Health Sciences,United Arab Emirates University,Al Ain,United Arab Emirates8.Department of Psychiatry,The First Hospital of Hebei Medical University,Shijiazhuang,Hebei Province,China;Mental Health Institute of Hebei Medical University,Shijiazhuang,Hebei Province,China9.Neuroscience Center,King Fahad Specialist Hospital,Dammam,Saudi Arabia
摘要：Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer's disease.The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes.Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes(e.g.,mouse,human,and rat)and their corresponding cell types,their organ-specific transcriptomes,and the tissue involved in aging.Traditional gene controllers such as DNA-and RNA-binding proteins significantly influence such programs,causing the need to sort out long non-coding RNAs,a new class of powerful gene regulatory elements.However,their functional significance in the aging process and senescence has yet to be investigated and identified.Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs.In this review article,we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes,including cellular senescence,aging,and age-related pathogenesis,which are the major hallmarks of long non-coding RNAs in aging.
机标关键词：molecularlongrnasagingassociateddiseaseseffecthallmarks
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 959-968 )
英文信息