Vimentin as a potential target for diverse nervous system diseases
Kang-Zhen Chen1
Shu-Xian Liu2
Yan-Wei Li2
Tao He3
Jie Zhao3
Tao Wang4
Xian-Xiu Qiu3
Hong-Fu Wu1
1.Department of Anesthesiology,Guangzhou Huadu Hospital Affiliated to Guangdong Medical University(Guangzhou Huadu District Maternal and Child Health Care Hospital),Guangzhou,Guangdong Province,China;Dongguan City Key Laboratory of Stem Cell and Regenerative Tissue Engineering,Guangdong Medical University,Dongguan,Guangdong Province,China2.Department of Anesthesiology,Guangzhou Huadu Hospital Affiliated to Guangdong Medical University(Guangzhou Huadu District Maternal and Child Health Care Hospital),Guangzhou,Guangdong Province,China3.Dongguan City Key Laboratory of Stem Cell and Regenerative Tissue Engineering,Guangdong Medical University,Dongguan,Guangdong Province,China4.Department of Surgery,the Third Hospital of Guangdong Medical University(Longjiang Hospital of Shunde District),Foshan,Guangdong Province,China
摘要：Vimentin is a major type III intermediate filament protein that plays important roles in several basic cellular functions including cell migration,proliferation,and division.Although vimentin is a cytoplasmic protein,it also exists in the extracellular matrix and at the cell surface.Previous studies have shown that vimentin may exert multiple physiological effects in different nervous system injuries and diseases.For example,the studies of vimentin in spinal cord injury and stroke mainly focus on the formation of reactive astrocytes.Reduced glial scar,increased axonal regeneration,and improved motor function have been noted after spinal cord injury in vimentin and glial fibrillary acidic protein knockout(GFAP-/-VIM-/-)mice.However,attenuated glial scar formation in post-stroke in GFAP-/-VIM-/-mice resulted in abnormal neuronal network restoration and worse neurological recovery.These opposite results have been attributed to the multiple roles of glial scar in different temporal and spatial conditions.In addition,extracellular vimentin may be a neurotrophic factor that promotes axonal extension by interaction with the insulin-like growth factor 1 receptor.In the pathogenesis of bacterial meningitis,cell surface vimentin is a meningitis facilitator,acting as a receptor of multiple pathogenic bacteria,including E.coli K1,Listeria monocytogenes,and group B streptococcus.Compared with wild type mice,VIM-/-mice are less susceptible to bacterial infection and exhibit a reduced inflammatory response,suggesting that vimentin is necessary to induce the pathogenesis of meningitis.Recently published literature showed that vimentin serves as a double-edged sword in the nervous system,regulating axonal regrowth,myelination,apoptosis,and neuroinflammation.This review aims to provide an overview of vimentin in spinal cord injury,stroke,bacterial meningitis,gliomas,and peripheral nerve injury and to discuss the potential therapeutic methods involving vimentin manipulation in improving axonal regeneration,alleviating infection,inhibiting brain tumor progression,and enhancing nerve myelination.
机标关键词：vimentintargetsystemdiseasesdiversenervouspotential
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 969-975 )
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