Anti-lgLON5 disease:a novel topic beyond neuroimmunology
Yi-ZongHeng Zhang1
You Ni1
Yi-Ning Gao1
Ding-Ding Shen2
Lu He1
Dou Yin1
Huan-Yu Meng1
Qin-Ming Zhou1
Ji Hu3
Sheng Chen2
1.Department of Neurology&Institute of Neurology,Ruijin Hospital,Affiliated with Shanghai Jiao Tong University School of Medicine,Shanghai,China2.Department of Neurology&Institute of Neurology,Ruijin Hospital,Affiliated with Shanghai Jiao Tong University School of Medicine,Shanghai,China;Co-lnnovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China3.Co-lnnovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China;School of Life Science and Technology,ShanghaiTech University,Shanghai,China;Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai,China
摘要：Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against lgLON5.Given its broad clinical spectrum and extremely complex pathogenesis,as well as difficulties in its early diagnosis and treatment,anti-lgLON5 disease has become the subject of considerable research attention in the field of neuroimmunology.Anti-IgLON5 disease has characteristics of both autoimmunity and neurodegeneration due to the unique activity of the anti-lgLON5 antibody.Neuropathologic examination revealed the presence of a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum,potentially broadening our understanding of tauopathies.In contrast to that seen with other autoimmune encephalitis-related antibodies,basic studies have demonstrated that lgLON5 antibody-induced neuronal damage and degeneration are irreversible,indicative of a potential link between autoimmunity and neurodegeneration in anti-lgLON5 disease.Herein,we comprehensively review and discuss basic and clinical studies relating to anti-lgLON5 disease to better understand this complicated disorder.
机标关键词：beyondtopicnovelanti-lglon5diseaseneuroimmunology
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1017-1022 )
英文信息