Neuroinflammation and glial activation in the central nervous system:a metabolic perspective
Assunta Virtuoso
Ciro De Luca
Sohaib Ali Korai
Michele Papa
Giovanni Cirillo
Division of Human Anatomy,Laboratory of Morphology of Neuronal Networks and Systems Biology,Department of Mental and Physical Health and Preventive Medicine,University of Campania"LuigiiVanvitelli",Naples,Italy
摘要：Decades of research in glial biology have investigated mechanisms of neuro-glial interplay,demonstrating that neurons and glia intimately cooperate for energy metabolism in the central nervous system(CNS)(Magistretti and Allaman,2018).As neurons invest their adenosine triphosphate in the neurotransmission,glial cells work to support neurons,providing metabolic substrates.Astrocytes,in particular,contribute largely to energy metabolism in CNS:they sense and shuttle nutrients(e.g.,glucose and lipids)and hormones(e.g.,insulin),accumulate and utilize glycogen for brain demands,influencing their own metabolism and neuronal activity by lactate transport(astrocyte-neuron lactate shuttle).
机标关键词：metaboliccentralsystemactivationeuroglialinflammationnervous
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1025-1026 )