Olfactory dysfunction as a common biomarker for neurodegenerative and neuropsychiatric disorders
David Slabik1
Olga Garaschuk2
1.Department of Psychiatry and Psychotherapy,Tubingen Center for Mental Health,Eberhard Karls University of Tubingen,Tubingen,Germany2.Institute of Physiology,Department Neurophysiology,Eberhard Karls University of Tubingen,Tubingen,Germany
摘要：The sense of smell supports the identification and the safety of food,warns of danger/predators,and plays a key role in mating(Croy and Hummel,2017;Kondo et al.,2020;Tzeng et al.,2021).Via connection to the limbic system,it supports behavioral adaption and emotions and can detect fear,tears,and happiness in the body odor of others(Croy and Hummel,2017;Tzeng et al.,2021).Sensory information is transmitted from the olfactory receptor neurons in the nose via the olfactory bulb(OB)to higher-order olfactory structures including the anterior olfactory nucleus,the piriform and entorhinal cortices,amygdala,hippocampus,orbitofrontal and prefrontal cortices,and nucleus accumbens(Croy and Hummel,2017;Marin et al.,2018).In the OB,axons from olfactory receptor neurons synapse on the dendrites of OB projection neurons mitral(MCs)and tufted cells in so-called glomeruli(Marin et al.,2018).
机标关键词：neurodcommonropsbiomarkerdegenerativedisordersdysfunctionolfactory
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1029-1030 )