Mechanotransduction mechanisms in central nervous system glia
Brenan Cullimore1
Jackson Baumann2
Christopher N.Rudzitis1
Andrew O.Jo1
Denisa Kirdaiova3
David Kri?aj1
1.Department of Ophthalmology and Visual Sciences,University of Utah School of Medicine,Salt Lake City,UT,USA2.Department of Ophthalmology and Visual Sciences,University of Utah School of Medicine,Salt Lake City,UT,USA;Department of Cellular Neurophysiology,Institute of Experimental Medicine,Czech Academy of Sciences,Prague,Czech Republic3.Department of Cellular Neurophysiology,Institute of Experimental Medicine,Czech Academy of Sciences,Prague,Czech Republic
摘要：Mechanical forces shape the development,function,and survival of every cell within the central nervous system(CNS)but are particularly important for astroglia,a subtype of glial cell that mediates communication between neurons and blood vessels.Astrocytes utilize changes in intracellular concentration of the 2nd messenger calcium[Ca2+]i to integrate local electrical,chemical,and mechanical microenvironments,with Ca2+-dependent release of gliotransmitters and cytokines implicated in the regulation of neurovascular coupling,short-and long-term synaptic plasticity,and neuronal excitability.These functions may be perturbed by age,tissue swelling(edema),ischemia,physical trauma,and chronic elevations in intraocular or intracranial pressure,to produce a reactive response that manifests as increases in hypertrophy,cell proliferation,and proinflammatory signaling.Astroglial activation by acute and chronic mechanical trauma compromises the integrity of blood-CNS barriers and neuronal function yet information about molecular sensors that transduce mechanical forces into astroglial[Ca2+]i is surprisingly sparse.We know that large tissue deformations that activate astroglia and injure CNS induce[Ca2+]i elevations(Rzigalinski et al.,1998;Lindqvist et al.,2010)but it is not known whether the cells are capable of responding to physiological deformations of the extracellular matrix(＜5％strain)and what such force transducers might be.
机标关键词：centralsystemotragliamechanismsnervoustransduction
论文发表日期：2023-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1031-1032 )