Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration
Irene Villalón-García
Suleva Povea-Cabello
Mónica álvarez-Córdoba
Marta Talaverón-Rey
Juan M.Suárez-Rivero
Alejandra Suarez-Carrillo
Manuel Munuera-Cabeza
Diana Reche-López
Paula Cilleros-Holgado
Rocío Pi?ero-Pérez
José A.Sánchez-Alcázar
Centro Andaluz de Biología del Desarrollo(CABD-CSIC-Universidad Pablo de Olavide de Sevilla),and Centro de Investigación Biomédica en Red:Enfermedades Raras,Instituto de Salud Carlos Ⅲ,Sevilla,Spain
摘要：Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases,such as Alzheimer's,Parkinson's,and Huntington's diseases,or neurodegeneration with brain iron accumulation disorders.Mitochondrial dysfunction,lipofuscin accumulation,autophagy disruption,and ferroptosis have been implicated as the critical pathomechanisms of lipid peroxidation and iron accumulation in these disorders.Currently,the connection between lipid peroxidation and iron accumulation and the initial cause or consequence in neurodegeneration processes is unclear.In this review,we have compiled the known mechanisms by which lipid peroxidation triggers iron accumulation and lipofuscin formation,and the effect of iron overload on lipid peroxidation and cellular function.The vicious cycle established between both pathological alterations may lead to the development of neurodegeneration.Therefore,the investigation of these mechanisms is essential for exploring therapeutic strategies to restrict neurodegeneration.In addition,we discuss the interplay between lipid peroxidation and iron accumulation in neurodegeneration,particularly in PLA2G6-associated neurodegeneration,a rare neurodegenerative disease with autosomal recessive inheritance,which belongs to the group of neurodegeneration with brain iron accumulation disorders.
机标关键词：neurodcycleaccumulationdegenerationironlipidperoxidationvicious
论文发表日期：2023-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1196-1202 )
英文信息