The lymphatic system:a therapeutic target for central nervous system disorders
Jia-Qi Xu1
Qian-Qi Liu2
Sheng-Yuan Huang3
Chun-Yue Duan2
Hong-Bin Lu4
Yong Cao2
Jian-Zhong Hu2
1.Department of Spine Surgery and Orthopaedics,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Changsha,Hunan Province,China;Mobiile Health Ministry of Education-China Mobile Joint Laboratory,Changsha,Hunan Province,China;National Clinical Research2.Department of Spine Surgery and Orthopaedics,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Changsha,Hunan Province,China;Mobiile Health Ministry of Education-China Mobile Joint Laboratory,Changsha,Hunan Province,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China3.Department of Cardiovascular Surgery,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China4.Key Laboratory of Organ Injury,Aging and Regenerative Medicine of Hunan Province,Changsha,Hunan Province,China;Mobiile Health Ministry of Education-China Mobile Joint Laboratory,Changsha,Hunan Province,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Department of Sports Medicine,Xiangya Hospital,Central South University,Changsha,Hunan Province,China
摘要：The lymphatic vasculature forms an organized network that covers the whole body and is involved in fluid homeostasis,metabolite clearance,and immune surveillance.The recent identification of functional lymphatic vessels in the meninges of the brain and the spinal cord has provided novel insights into neurophysiology.They emerge as major pathways for fluid exchange.The abundance of immune cells in lymphatic vessels and meninges also suggests that lymphatic vessels are actively involved in neuroimmunity.The lymphatic system,through its role in the clearance of neurotoxic proteins,autoimmune cell infiltration,and the transmission of pro-inflammatory signals,participates in the pathogenesis of a variety of neurological disorders,including neurodegenerative and neuroinflammatory diseases and traumatic injury.Vascular endothelial growth factor C is the master regulator of lymphangiogenesis,a process that is critical for the maintenance of central nervous system homeostasis.In this review,we summarize current knowledge and recent advances relating to the anatomical features and immunological functions of the lymphatic system of the central nervous system and highlight its potential as a therapeutic target for neurological disorders and central nervous system repair.
机标关键词：centralsystemtargetdisorderslymphaticnervoustherapeutic
论文发表日期：2023-06-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1249-1256 )
英文信息