Alzheimer's disease risk after COVID-19: a view from the perspective of the infectious hypothesis of neurodegeneration
Eugenia Olivera
Albany Sáez
Lila Carniglia
Carla Caruso
Mercedes Lasaga
Daniela Durand
Instituto de Investigaciones Biomédicas INBIOMED UBA-CONICET,Facultad de Medicina,Universidad de Buenos Aires,Argentina
摘要：In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration, we aimed at revisiting the infectious hypothesis of Alzheimer's disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration. We wondered how SARS-CoV-2 could be related to the amyloid-β cascade and how it could lead to the pathological hallmarks of the disease. We also predict a paradigm change in clinical medicine, which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer's disease.
机标关键词：alzheimercovid-19neurodriskafterviewfromdegeneration
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1404-1410 )
英文信息