Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface
Dan-Dan Liu1
Chao-Yang Zhang2
Jing-Ting Zhang2
Li-Min Gu3
Guo-Tong Xu1
Jing-Fa Zhang2
1.Department of Ophthalmology of Tongji Hospital,Tongji Eye Institute,Department of Regenerative Medicine,and Department of Pharmacology,Tongji University School of Medicine,Shanghai,China2.Department of Ophthalmology,Shanghai General Hospital(Shanghai First People's Hospital),Shanghai Jiao Tong University,Shanghai,China;National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,Shanghai,China3.Department of Ophthalmology,Shanghai Aier Eye Hospital,Shanghai,China
摘要：Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic retinopathy despite tight control of glucose levels. The underlying mechanisms of epigenetic modifications in diabetic retinopathy still urgently need to be elucidated. The diabetic condition facilitates epigenetic changes and influences target gene expression. In this review, we summarize the involvement of epigenetic modifications and metabolic memory in the development and progression of diabetic retinopathy and propose novel insights into the treatment of diabetic retinopathy.
机标关键词：metabolicmemorybeyondsurfacediabeticepigeneticmodificationsretinopathy
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1441-1449 )
英文信息