Stem cell therapy in retinal diseases
Audrey Voisin1
Amaury Pénaguin2
Afsaneh Gaillard3
Nicolas Leveziel1
1.Laboratoire de Neurosciences Expérimentales et Cliniques,Universitéde Poitiers,INSERM 1084,Poitiers,France;Department of Ophthalmology,CHU Poitiers,Poitiers,France2.Laboratoire de Neurosciences Expérimentales et Cliniques,Universitéde Poitiers,INSERM 1084,Poitiers,France;Laboratoires Thea,Clermont-Ferrand,France3.Laboratoire de Neurosciences Expérimentales et Cliniques,Universitéde Poitiers,INSERM 1084,Poitiers,France
摘要：Alteration of the outer retina leads to various diseases such as age-related macular degeneration or retinitis pigmentosa characterized by decreased visual acuity and ultimately blindness. Despite intensive research in the field of retinal disorders, there is currently no curative treatment. Several therapeutic approaches such as cell-based replacement and gene therapies are currently in development. In the context of cell-based therapies, different cell sources such as embryonic stem cells, induced pluripotent stem cells, or multipotent stem cells can be used for transplantation. In the vast majority of human clinical trials, retinal pigment epithelial cells and photoreceptors are the cell types considered for replacement cell therapies. In this review, we summarize the progress made in stem cell therapies ranging from the pre-clinical studies to clinical trials for retinal disease.
机标关键词：stemcelldiseasesretinaltherapy
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1478-1485 )
英文信息