Functional hyperconnectivity related to brain disease: maladaptive process or element of resilience?
Markus Aswendt1
Mathias Hoehn2
1.Department of Neurology,Faculty of Medicine and University Hospital Cologne,University of Cologne,Cologne,Germany;Cognitive Neuroscience,Institute of Neuroscience and Medicine(INM-3),Research Center Juelich,Juelich,Germany2.Cognitive Neuroscience,Institute of Neuroscience and Medicine(INM-3),Research Center Juelich,Juelich,Germany
摘要：Neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography provide unique in vivo data to analyze structural and functional connectivity of the whole brain. Recent advances in small animal neuroimaging have opened new opportunities for the study of structure-function interactions in healthy and diseased brain networks, which are essential to develop therapies targeting network reorganization associated with functional improvement. Based on clinical studies, a common network response to acute neurological insult (e.g., stroke) and neurodegeneration (e.g., Alzheimer's disease) is hyperconnectivity, i.e., an increase of functional connectivity strength above (healthy) control levels, a process which is, however, not well understood. For example, in resting-state functional MRI (rs-fMRI), which measures the hemodynamic response to neuronal activity, hyperconnectivity would refer to a drastic increase in the correlation between two regional time series. In absence of an absolute threshold defining hyperconnectivity, it relates to a control group or baseline measurement before intervention.
机标关键词：resilienceelementprocessbrainpercconnectivitydiseasefunctional
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1489-1490 )