Pemafibrate, a potent selective peroxisome proliferator-activated receptor α modulator, a promising novel treatment for ischemic retinopathy?
Deokho Lee
Yohei Tomita
Kazuno Negishi
Toshihide Kurihara
Department of Ophthalmology,Keio University School of Medicine,Shinanomachi,Shinjuku-ku,Japan
摘要：Ischemic retinopathy is a retinal disease caused by ischemic attacks. Ischemia is a common pathologic mechanism in various retinal disorders and diseases such as age-related macular degeneration, diabetic retinopathy, glaucoma, or vascular occlusion (Osborne et al., 2004). Although various murine models have been developed to understand a series of metabolic mechanisms induced by retinal ischemia and further used to test promising therapeutics, effective treatment in ischemic retinopathy has not been clearly suggested. This is associated with the notion that the contributing pathologic metabolic pathways might be enormously complex.
机标关键词：receptornovelactivatedischemicmodulatorpemafibrateperoxisomepotent
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1495-1496 )