From dolphins to dogs: new opportunities to understand the role of P2X4 receptors in spinal cord injury and neuropathic pain
Reece A.Sophocleous
Ronald Sluyter
Illawarra Health and Medical Research Institute,Wollongong,NSW,Australia;Molecular Horizons and School of Chemistry and Molecular Bioscience,University of Wollongong,Wollongong,NSW,Australia
摘要：The P2X4 receptor belongs to the P2X receptor family of trimeric ligand-gated ion channels and was the first member of this family for which a crystal structure was obtained (Kawate et al., 2009). This structure confirmed the trimeric stoichiometry of P2X receptors and subsequent studies from the same group revealed the orthosteric binding site of the natural ligand adenosine 5′-triphosphate (ATP) in a cleft between each adjacent subunit (Hattori and Gouaux, 2012). Now synonymous with structural descriptions of P2X receptors, these original studies described the structure of each P2X4 receptor subunit as that resembling a dolphin, with the two transmembrane domains representing the fluke and the extracellular loop representing the upper body, including the head, dorsal fin, and left and right flippers.
机标关键词：rolecordfromdogsdolphinsinjuryneuropathicopportunities
论文发表日期：2023-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1497-1498 )