Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury
Yao Shen
Yi-Piao Wang
Xin Cheng
Xuesong Yang
Guang Wang
Division of Histology and Embryology,International Joint Laboratory for Embryonic Development&Prenatal Medicine,Medical College,Jinan University,Guangzhou,GuangdongProvince,China;Key Laboratory for Regenerative Medicine of the Ministry of Education,Jinan University,Guangzhou,Guangdong Province,China
摘要：Stem cells are a group of cells with unique self-renewal and differentiation abilities that have greatprospects in the repair of spinal cord injury. However, stem cell renewal and differentiation require strict control of protein turnover in the stem cells to achieve cell remodeling. As a highly conserved "gatekeeper" of cell homeostasis, autophagy can regulate cell remodeling by precisely controlling protein turnover in cells. Recently, it has been found that the expression of autophagy markers changes in animal models of spinal cord injury. Therefore, understanding whether autophagy can affect the fate of stem cells and promote the repair of spinal cord injury is of considerable clinical value. This review expounds the importance of autophagy homeostasis control for the repair of spinal cord injury from three aspects—pathophysiology of spinal cord injury, autophagy and stem cell function, and autophagy and stem cell function in spinal cord injury—and proposes the synergistic therapeutic effect of autophagy and stem cells in spinal cord injury.
机标关键词：stemcordcellwithautophagycombinedinjuryregulation
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 1629-1636 )
英文信息