The role of monocytes in optic nerve injury
Xiangxiang Liu1
Yuan Liu2
Mohamed M.Khodeiry2
Richard K.Lee2
1.Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing,China;Bascom Palmer Eye Institute,Department of Ophthalmology,University of Miami Miller School of Medicine,Miami,FL,USA2.Bascom Palmer Eye Institute,Department of Ophthalmology,University of Miami Miller School of Medicine,Miami,FL,USA
摘要：Monocytes, including monocyte-derived macrophages and resident microglia, mediate manyphases of optic nerve injury pathogenesis. Resident microglia respond first, followed by infiltrating macrophages which regulate neuronal inflammation, cell proliferation and differentiation, scar formation and tissue remodeling following optic nerve injury. However, microglia and macrophages have distinct functions which can be either beneficial or detrimental to the optic nerve depending on the spatial context and temporal sequence of their activity. These divergent effects are attributed to pro- and anti-inflammatory cytokines expressed by monocytes, crosstalk between monocyte and glial cells and even microglia-macrophage communication. In this review, we describe the dynamics and functions of microglia and macrophages in neuronal inflammation and regeneration following optic nerve injury, and their possible role as therapeutic targets for axonal regeneration.
机标关键词：opticroleinjurymonocytesnerve
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1666-1671 )
英文信息