Augmentation of transforminggrowth factor-β signaling for the treatment of neurological disorders
Jian Luo
Palo Alto Veterans Institute for Research,VA Palo Alto Health Care System,Palo Alto,CA,USA
摘要：Members of the transforming growth factor-β (TGF-β) superfamily perform a wide range of essential functions during development and in adulthood, as well as in response to injury and inflammation (Luo, 2022). In the adult central nervous system, TGF-βs and their receptors are widely expressed in all of the major neuronal, glial, and vascular cell types. Members of the TGF-β superfamily are pivotal responders to pathological insults to the brain. Dysfunction of TGF-β signaling contributes to pathogenesis of neurological disorders. Manipulation of TGF-β signaling pathway alters pathological and functional outcomes in models of neurological diseases (Luo, 2022). Therefore, the TGF-β signaling pathway has emerged as a potential therapeutic target against neurological diseases.
机标关键词：transformgrowthaugmentationdisordersfactor-formingneurologicalsignaling
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1711-1712 )