Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation
Dumitru Ciolac1
Gabriel Gonzalez-Escamilla2
Yaroslav Winter3
Vinzenz Fleischer2
Matthias Grothe4
Sergiu Groppa2
1.Department of Neurology,Focus Program Translational Neuroscience,Rhine Main Neuroscience Network(rmn2),University Medical Center of the Johannes Gutenberg University Mainz,Mainz,Germany;State University of Medicine and Pharmacy"Nicolae Testemitanu",Chisinau,Republic of Moldova;Department of Neurology,Institute of Emergency Medicine,Chisinau,Republic of Moldova2.Department of Neurology,Focus Program Translational Neuroscience,Rhine Main Neuroscience Network(rmn2),University Medical Center of the Johannes Gutenberg University Mainz,Mainz,Germany3.Mainz Comprehensive Epilepsy and Sleep Medicine Center,Department of Neurology,Johannes Gutenberg University Mainz,Mainz,Germany;Department of Neurology,Philipps-University,Marburg,Germany4.Department of Neurology,Heinrich Heine University,Düsseldorf,Germany
摘要：Multiple sclerosis (MS), the most commoninflammatory condition of the central nervoussystem in young adults, is characterized by immune-mediated demyelination and neurodegeneration thattranslate into heterogeneous clinical phenotypes anddisease trajectories. Although focal demyelinatinglesions within the white matter are the hallmark ofMS pathology, a large amount of lesions has beendetected in both cortical and subcortical grey mattertissue. Besides focal pathology, diffuse inflammationand axonal damage are increasingly recognized innormal appearing white matter, as well as grey matter.Among various clinical manifestations, patients withMS may experience epileptic seizures, which canemerge at any time point throughout the diseasecourse. Several clinical factors such as earlier onset ofMS, longer disease duration, and higher disability havebeen related to the increased prevalence of epilepsyin patients with MS (Neu? et al., 2020; Grothe et al.,2021). Acute seizures and epilepsy were also reportedin other neuroinflammatory disorders of the centralnervous system, e.g., in myelin oligodendrocyteglycoprotein antibody disease, acute disseminatedencephalomyelitis or neuromyelitis optica spectrumdisorder. A few available neuroimaging andneuropathological studies suggested that the extent ofcortical grey matter damage is proportional to the riskof epilepsy occurrence in patients with MS (Calabreseet al., 2012; Nicholas et al., 2016). However, despitethe significant progress achieved in elucidatingthe molecular and cellular basis of MS pathology,mechanisms of increased susceptibility to seizuregeneration in acute and chronic neuroinflammationare poorly understood, thereby, leaving manyquestions open. Only a few to list: what are the brainstructural fingerprints of epileptic seizures in MS? Isthe location of tissue damage within a particular brainregion (e.g., hippocampus or thalamus) is criticalfor initiating epilepsy? Is there a specific "networkcorrelate" of hyperexcitable neuronal circuits anddo they render networks vulnerable to ongoing MS-mediated damage? And finally, what are the main"culprit mechanisms" responsible for ictogenesis andepileptogenesis in MS? Based on the aforementionedquestions, the overarching aim of this perspectivearticle was to portray the brain network correlatesof epilepsy occurrence in MS. First, we describestructural abnormalities of brain tissue associatedwith a higher susceptibility of epilepsy occurrence.Afterwards, we highlight the network alterations thatare linked to epileptogenesis in patients with MSand explain the candidate molecular mechanismsunderlying network hyperexcitability. Finally, weprovide a conceptual background for future studies.
机标关键词：networkbraincorrelatesepilepsyeuroinflammationmultipleoccurrence
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1717-1718 )