Oxidative stress in N88S seipinopathy: novel insights into the mechanisms of neurodegeneration and therapeutic avenues
Vítor Costa1
Vitor Teixeira2
1.i3S-Instituto de Investiga??o e Inova??o em Saúde,Universidade do Porto,Porto,Portugal;Yeast Signalling Networks,IBMC-Instituto de Biologia Molecular e Celular,Universidade do Porto,Porto,Portugal;ICBAS,Instituto de Ciências Biomédicas Abel 2.i3S-Instituto de Investiga??o e Inova??o em Saúde,Universidade do Porto,Porto,Portugal;Yeast Signalling Networks,IBMC-Instituto de Biologia Molecular e Celular,Universidade do Porto,Porto,Portugal
摘要：Lipid droplets (LDs) are ubiquitous cellular organelles that perform functions mostly dedicated to energy homeostasis and lipid metabolism. As neutral lipid depots (triacylglycerol, sterol esters), they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy, a specific form of autophagy devoted to consumption of LDs inside the lysosome. These processes usually reflect adaptation to changes in nutrient availability and membrane buildup during active growth. LDs also contribute to buffering of unsaturated fatty acids, and prevent cellular accumulation of oxidized and peroxidized lipids, thereby providing immediate protection against lipotoxicity and oxidative stress.
机标关键词：insightsneurodstressnovelavenuesdegenerationintomechanisms
论文发表日期：2023-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1719-1720 )