Brain organoids are new tool for drug screening of neurological diseases
Jin-Qi Zhou
Ling-Hui Zeng
Chen-Tao Li
Da-Hong He
Hao-Duo Zhao
Yan-Nan Xu
Zi-Tian Jin
Chong Gao
School of Medicine,Institute of Brain and Cognitive Science,Hangzhou City University,Hangzhou,Zhejiang Province,China;Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou,Zhejiang Province,China
摘要：At the level of in vitro drug screening,the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening.There are few systematic reports on brain organoids,as a new three-dimensional in vitro model,in terms of model stability,key phenotypic fingerprint,and drug screening schemes,and particularly regarding the development of screening strategies for massive numbers of traditional Chinese medicine monomers.This paper reviews the development of brain organoids and the advantages of brain organoids over induced neurons or cells in simulated diseases.The paper also highlights the prospects from model stability,induction criteria of brain organoids,and the screening schemes of brain organoids based on the characteristics of brain organoids and the application and development of a high-content screening system.
机标关键词：screeningbraindiseasesdrugneurologicalorganoidstool
论文发表日期：2023-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1884-1889 )
英文信息