New insights into the biological roles of immune cells in neural stem cells in post-traumatic injury of the central nervous system
Ning He1
Xing-Jia Mao1
Yue-Min Ding2
Tong Zuo3
Ying-Ying Chen4
Lin-Lin Wang1
1.Department of Basic Medicine Sciences,and Department of Orthopaedics of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China2.School of Medicine,Hangzhou City University,Hangzhou,Zhejiang Province,China3.Universiity of Chicago College,University of Chicago,Chicago,IL,USA4.Department of Basic Medicine Sciences,and Department of Obstetrics of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China
摘要：Traumatic injuries in the central nervous system,such as traumatic brain injury and spinal cord injury,are associated with tissue inflammation and the infiltration of immune cells,which simultaneously affect the self-renewal and differentiation of neural stem cells.However,the tissue repair process instigated by endogenous neural stem cells is incapable of restoring central nervous system injuries without external intervention.Recently,resident/peripheral immune cells have been demonstrated to exert significant effects on neural stem cells.Thus,the restoration of traumatic injuries in the central nervous system by the immune intervention in neural stem cells represents a potential therapeutic method.In this review,we discuss the roles and possible mechanisms of immune cells on the self-renewal and differentiation of neural stem cells along with the prognosis of central nervous system injuries based on immune intervention.Finally,we discuss remaining research challenges that need to be considered in the future.Further elucidation of these challenges will facilitate the successful application of neural stem cells in central nervous system injuries.
机标关键词：insightscentralcellssystembiologicalimmuneinjuryinto
论文发表日期：2023-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1908-1916 )
英文信息