Neurodevelopmental defects as a primer of neurodegeneration:lessons from spinal muscular atrophy and Huntington's disease
Stuart J.Grice
Ji-Long Liu
Medical Research Council Functional Genomics Unit,Department of Physiology,Anatomy and Genetics,University of Oxford,Oxford,UK(Grice SJ,Liu JL)School of Life Science and Technology,ShanghaiTech University,Shanghai,China(Liu JL
摘要：Developmental motifs in neurodegeneration:Neurodegeneration,the prominent feature of neurodegenerative disease,is characterized by the progressive and selective loss of neuronal function.As some of the pathologies caused by neurodegeneration may be irreversible,early intervention will be required for the treatments that aim to slow or halt the manifestation of these diseases.Traditionally,neurodegeneration evokes the idea of a progressive decline of brain function,which ultimately ends with the loss of cognitive,sensory,or motor ability,and the death of specific neuronal subtypes.However,it is now starting to emerge that some neurodegenerative diseases may be caused,or at least become primed,by defects that arise during neurodevelopment.
机标关键词：huntingtonneurodprimerfromatrophydefectsdegenerationdevelopmental
论文发表日期：2023-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1952-1953 )