Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer 's disease pathogenesis
Jason HY Yeung1
Andrea Kwakowsky2
1.Centre for Brain Research,Department of Anatomy and Medical Imaging,Faculty of Medical and Health Sciences,University of Auckland,Auckland,New Zealand2.Centre for Brain Research,Department of Anatomy and Medical Imaging,Faculty of Medical and Health Sciences,University of Auckland,Auckland,New Zealand;Pharmacology and Therapeutics,School of Medicine,Galway Neuroscience Centre,Ollscoil na Gaillimhe-University of Galway,Galway,Ireland
摘要：Alzheimer's disease (AD) is the leading neurodegenerative disorder globally. Despite this, there is minimal effective therapeutics proven to reduce or prevent the progression of this disease. Glutamate is the main excitatory neurotransmitter within the central nervous system and plays a crucial role in neuronal and synaptic functions. As such, the glutamatergic system is finely regulated within normal physiology, with multiple mechanisms to prevent excessive or insufficient glutamatergic receptor activation.
机标关键词：receptoralzheimervariantalphawithdiseaseglutamateimplications
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2196-2197 )