Multi-faceted small molecule for Alzheimer 's disease
Min Hee Park1
Hee Kyung Jin2
Jae-sung Bae1
1.KNU Alzheimer's Disease Research Institute,Department of Physiology,School of Medicine,Kyungpook National University,Daegu,South Korea2.KNU Alzheimer's Disease Research Institute,Department of Laboratory Animal Medicine,College of Veterinary Medicine,Kyungpook National University,Daegu,South Korea
摘要：The main pathologies of Alzheimer's disease (AD) are the accumulation of amyloid-β (Aβ) and tau tangles, and these two fundamental pathologies accompany the various neuropathological features, such as neuroinflammation, loss of synapse and neurogenesis, disruption of the blood-brain barrier (BBB), autophagy dysfunction, and cognitive impairment (Lee et al., 2014; Sweeney et al., 2018; Kashyap et al., 2019; Park et al., 2022). AD is thus considered a multi-factorial disease in which each of these complex neuropathological features somehow interrelates, eventually leading to neuronal and functional loss in the nervous system.
机标关键词：alzheimersmalldiseasemoleculemulti-faceted
论文发表日期：2023-10-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2198-2199 )