Targeting TRPM2- and TRPM4- extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke
Pengyu Zong
Cindy X.Li
Jianlin Feng
Lixia Yue
Department of Cell Biology,Calhoun Cardiology Center,UConn Health,Farmington,CT,USA
摘要：Ischemic stroke represents a heavy burden on public health. Currently, recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients. However, there is no effective adjunct medication for preventing neuron loss after reperfusion to mitigate long-lasting brain injury. Extrasynaptic N-methyl-D-aspartate receptors (esNMDARs) are the major cause of ischemic neuronal death. However, there is no inhibitor selectively targeting esNMDARs without compromising the function of other "beneficial" synaptic NMDARs, which is due to the limited understanding of the underlying molecular mechanisms. Recently, two members of the transient receptor potential melastatin (TRPM) channel family, TRPM2 and TRPM4, were shown to be critical in amplifying esNMDAR-mediated neurotoxic effects during ischemic stroke without influencing the functions of synaptic NMDAR. Targeting the interaction between TRPM2- and TRPM4-esNMDAR provides a novel strategy in screening effective drugs for ischemic stroke.
机标关键词：receptorcouplingstrokeaspartateextrasynapticischemicmethyltargeting
论文发表日期：2023-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2383-2384 )