Mechanosensitive Piezo1 channel regulation of microglial cell function and implications to neurodegenerative diseases and neuroinflammation
Mo Zhang1
Philippa Malko2
Lin-Hua Jiang3
1.Department of Physiology and Pathophysiology,and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province,Xinxiang Medical University,Xinxiang,Henan Province,China2.School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK3.Department of Physiology and Pathophysiology,and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province,Xinxiang Medical University,Xinxiang,Henan Province,China;School of Biomedical Sciences,Faculty of Biological Sciences,University of Leeds,Leeds,UK;A4245-Transplantation,Immunology and Inflammation,Faculty of Medicine,University of Tours,Tours,France
摘要：Microglial cells are the key immunocompetent cells in the central nervous system (CNS) and play a crucial role in CNS health and disease (Paolicelli et al., 2022). Under the homeostatic conditions, microglial cells assume diverse and dynamic states, depending upon interactions with neighboring cells and structures in local contextual settings, continuously patrol brain parenchyma utilizing their highly mobile fine processes, phagocytize protein aggregates, unwanted synapses and cells to maintain CNS health, and secrete neurotrophic factors to support neuronal function (Colonna and Butovsky, 2017; Paolicelli et al., 2022).
机标关键词：piezo1neurodchannelfunctioncelldegenerativediseasesimplications
论文发表日期：2023-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2385-2386 )