CD137L, a driver of harmful inflammation in the nervous system
Hiu Yi Wong1
Amanda C.Y.Chan2
Anselm Mak3
Herbert Schwarz4
1.Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China;Hong Kong Center for Neurodegenerative Diseases,Hong Kong Special Administrative Region, China2.Division of Neurology, University Medicine Cluster,National University Hospital, Singapore;Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore,Singapore;Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine,National University of Singapore, Singapore3.Division of Rheumatology, University Medicine Cluster, National University Health System,Department of Medicine, Yong Loo Lin School of Medicine, National Univesity of Singapore,Singapore4.Department of Physiology, and Immunology Programme, Yong Loo Lin School of Medicine,National University of Singapore, Singapore;Integrative Sciences and Engineering Programme,NUS Graduate School, National University of Singapore, Singapore
摘要：CD137 (TNFRSF9, 4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory molecule. High levels of CD137 are expressed on T cells upon activation. CD137 signaling in T cells, either by cognate interaction with antigen-presenting cells (APC) or by agonistic anti-CD137 antibodies, strongly enhances proliferation, interferon-γ secretion, and cytolytic activity of T cells.
机标关键词：driversystemharmfulinflammationnervous
论文发表日期：2023-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2387-2388 )