Targeting glial metabolism in neurodegenerative diseases: detail matters
Ruqayya Afridi
Kyoungho Suk
Department of Pharmacology,School of Medicine,Kyungpook National University,Daegu,South Korea;Department of Biomedical Sciences,BK21 PLUS KNU Biomedical Convergence Program,School of Medicine,Kyungpook National University,Daegu,South Korea;Brain Science and Engineering Institute,Kyungpook National University,Daegu,South Korea
摘要：Neurodegenerative diseases, a group of disorders associated with advanced age, are typified by the disease-specific accumulation of mutant proteins and neuroinflammation. For decades, treatment modalities for these disorders have focused on addressing neuronal malfunction, which has resulted in the failure of therapies. Recent studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory mediators. Glia, the major immune component of the central nervous system (CNS), undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al., 2022).
机标关键词：neuroddegenerativedetaildiseasesglialmattersmetabolismtargeting
论文发表日期：2023-11-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2393-2394 )