Cytokines,synaptic plasticity and network dynamics:a matter of balance
Laura Bellingacci
Jacopo Canonichesi
Andrea Mancini
Lucilla Parnetti
Massimiliano Di Filippo
Section of Neurology,Department of Medicine and Surgery,University of Perugia,Perugia,Italy
摘要：The modern view of the immune system as a sensitizing and modulating machinery of the central nervous system is now well recognized.However,the specific mechanisms underlying this fine crosstalk have yet to be fully disentangled.To control cognitive function and behavior,the two systems are engaged in a subtle interacting act.In this scenario,a dual action of pro-inflammatory cytokines in the modulation of brain network connections is emerging.Pro-inflammatory cytokines are indeed required to express physiological plasticity in the hippocampal network while being detrimental when over-expressed during uncontrolled inflammatory processes.In this dynamic equilibrium,synaptic functioning and the performance of neural networks are ensured by maintaining an appropriate balance between pro-and anti-inflammatory molecules in the central nervous system microenvironment.
机标关键词：balancedynamicsnetworkcytokinesmatterplasticitysynaptic
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 2569-2572 )
英文信息