Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?
Enrique Estudillo1
Adolfo López-Ornelas2
Alejandro Rodríguez-Oviedo3
Neptali Gutiérrez de la Cruz4
Marco Antonio Vargas-Hernández5
Adriana Jiménez6
1.Laboratorio de Reprogramación Celular,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez,Mexico City,Mexico2.División de Investigación,Hospital Juárez de México,Mexico City,Mexico;HospitalNacional Homeopático,Hospitales Federales de Referencia,Mexico City,Mexico3.Facultad de Ciencias,Universidad Nacional Autónoma de México,Mexico City,Mexico4.Laboratorio de Morfología,Escuela Militar de Graduados de Sanidad,Secretaría de la Defensa Nacional,Batalla de Celaya,Lomas de Sotelo,Miguel Hidalgo,Mexico City,Mexico;Escuela Militar de Graduados de Sanidad,Secretaría de la Defensa Nacional,Batalla de Celaya,Lomas de Sotelo,Miguel Hidalgo,Mexico City,Mexico5.Escuela Militar de Graduados de Sanidad,Secretaría de la Defensa Nacional,Batalla de Celaya,Lomas de Sotelo,Miguel Hidalgo,Mexico City,Mexico6.División de Investigación,Hospital Juárez de México,Mexico City,Mexico
摘要：The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of transport.Although brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or alpha-synuclein.Alzheimer's disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several groups.However,its impairment has barely been considered as a potential therapeutic target.Here we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ailment.Finally,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.
机标关键词：alzheimerblacktargetcellsbraindiseaseendothelialmain
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2592-2598 )
英文信息