Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease
Júlio César Claudino dos Santos1
Leandro Freitas Oliveira2
Felipe Micelli Noleto3
Camilla Teixeira Pinheiro Gusm?o4
Gerly Anne de Castro Brito5
Glauce Socorro de Barros Viana6
1.Christus University Center-UNICHRISTUS,Fortaleza,CE,Brazil;Postgraduate Program in Morphofunctional Sciences,Federal University of Ceará-UFC,Fortaleza,CE,Brazil2.Universidade Católica de Brasília-UCB,Brasília,DF,Brasil3.Christus University Center-UNICHRISTUS,Fortaleza,CE,Brazil4.Postgraduate Program in Physiology and Pharmacology Department of the Federal University of Ceará-UFC,Fortaleza,CE,Brazil5.Postgraduate Program in Morphofunctional Sciences,Federal University of Ceará-UFC,Fortaleza,CE,Brazil;Physiology and Pharmacology Department of the Federal University of Ceará-UFC,Fortaleza,CE,Brazil6.Physiology and Pharmacology Department of the Federal University of Ceará-UFC,Fortaleza,CE,Brazil
摘要：This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.
机标关键词：crosstalkparkinsonbetweenbrainaxisalpha-synucleindiseasemicrobiome
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 2611-2614 )
英文信息