Animal models of vascularized nerve grafts:a systematic review
Francesca Toia
Daniele Matta
Federico De Michele
Roberto Pirrello
Adriana Cordova
Plastic and Reconstructive Surgery.Department of Surgical,Oncological and Oral Sciences.University of Palermo,Palermo,Italy
摘要：The aim of this review is to present and compare the various animal models of vascularized nerve grafts described in the literature as well as to summarize preclinical evidence for superior functional results compared to non-vascularized free nerve grafts.We also will present the state of the art on prefabricated vascularized nerve grafts.A systematic literature review on vascularized nerve graft models was conducted via the retrieval with the PubMed database on March 30,2019.Data on the animal,nerve,and vascularization model,the recipient bed,the evaluation time points and methods,and the results of the study results were extracted and analyzed from selected articles.The rat sciatic nerve was the most popular model for vascularized nerve grafts,followed by the rabbit;however,rabbit models allow for longer nerve grafts,which are suitable for translational evaluation,and produced more cautious results on the superiority of vascularized nerve grafts.Compared to free nerve grafts,vascularized nerve grafts have better early but similar long-term results,especially in an avascular bed.There are few studies on avascular receiving beds and prefabricated nerve grafts.The clinical translation potential of available animal models is limited,and current experimental knowledge cannot fully support that the differences between vascularized nerve grafts and free nerve grafts yield a clinical advantage that justifies the complexity of the procedure.
机标关键词：reviewmodelsanimalgraftsnervesystematicvascularized
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 2615-2618 )
英文信息