Potential role of Lycium barbarum polysaccharides in glaucoma management:evidence from preclinical in vivo studies
Yamunadevi Lakshmanan1
Francisca Siu Yin Wong1
Kwok-Fai So2
Henry Ho-Lung Chan3
1.Centre for Eye and Vision Research(CEVR),17W Hong Kong Science Park,Hong Kong Special Administrative Region,China2.Guangdong-Hongkong-Macau(GHM)Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China;Department of Ophthalmology,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China3.Centre for Eye and Vision Research(CEVR),17W Hong Kong Science Park,Hong Kong Special Administrative Region,China;Laboratory of Experimental Optometry(Neuroscience),School of Optometry,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China;Research Centre for SHARP Vision(RCSV),The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China;University Research Facilities in Behavioral and Systems Neuroscience(UBSN),The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China
摘要：In recent years,the pharmacological benefits of herbal extracts have been revisited fortheir potential neuroprotective effects in glaucoma.The polysaccharides extracted from the fruits of Lycium barbarum L.,or Lycium barbarum polysaccharides,exert their anti-aging effect through reducing oxidative stress,modulating the immune response,enhancing neuronal responses,and promoting cytoprotection.The therapeutic efficacy of Lycium barbarum polysaccharides in preserving retinal ganglion cells and their functions was demonstrated in a range of experimental models of optic neuropathies.These include the acute and chronic ocular hypertension models,the partial optic nerve transection model,and the ischemic-reperfusion injuries model.Based on these findings,Lycium barbarum polysaccharides appear to be a good candidate to be developed as a neuroprotective agent for treating multifactorial diseases.This review aims to present a comprehensive review on the latest preclinical evidence on the pre-and post-treatment benefits of Lycium barbarum polysaccharides in retinal ganglion cell neuroprotection.The possible mechanisms of Lycium barbarum polysaccharides mediating retinal ganglion cell neuroprotection will also be described.Moreover,the potential research gaps in the effective translation of Lycium barbarum polysaccharides treatment into clinical glaucoma management will be discussed.
机标关键词：polysaccharidesmanagementbarbarumstudiesrolefromvivoevidence
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2623-2632 )
英文信息