Molecular chaperones in stroke-induced immunosuppression
Haoduo Qiao1
Qing Xu1
Yunfei Xu1
Yao Zhao1
Nina He1
Jie Tang2
Jie Zhao1
Ying Liu1
1.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Department of Pathophysiology,Xiangya School of Medicine,Central South University,Changsha,Hunan Province,China;Sepsis Translational Medicine Key Laboratory of Hunan Province,Changsha,Hunan Province,China;NationalMedicine Functional Experimental Teaching Center,Changsha,Hunan Province,China2.Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha,Hunan Province,China
摘要：Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections,such as urinary tract infections and stroke-associated pneumonia,worsening prognosis.Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains,refolding misfolded proteins,and targeting misfolded proteins for degradation.Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones,cochaperones,and their associated pathways.This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.
机标关键词：molecularchaperonesstroke-inducedsuppression
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2638-2644 )
英文信息