Focus on LPA signaling:a promising therapeutic target to foster regeneration in immune-mediated neuropathies
Fabian Szepanowski
Mark Stettner
Department of Neurology and Center for Translational and Behavioral Neurosciences(C-TNBS),University Medicine Essen,University Duisburg Essen,Essen,Germany
摘要：Lysophosphol ipids a re metabolites of glycerophospholipids and sphingolipids that are commonly found as lipid constituents of cell membranes.In addition to their function as structural membrane components,certain members of the lysophospholipid family have considerable cell signaling properties.Sphingosine-1-phosphate(S1P)and lysophosphatidic acid(LPA)represent the two major bioactive members of the lysophospholipid family that address specific G-protein coupled receptors,simply referred to as S1P(subtypes S1P1-5)and LPA(subtypes LPA1-6)receptors(Kano et al.,2022).
机标关键词：regenerationfocustargetfosterimmune-mediatedneuropathiespromisingsignaling
论文发表日期：2023-12-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2651-2652 )