Lactate metabolism in neurodegenerative diseases
Chaoguang Yang1
Rui-Yuan Pan2
Fangxia Guan3
Zengqiang Yuan2
1.The Brain Science Center,Beijing Institute of Basic Medical Sciences,Beijing,China;School of Life Sciences,Zhengzhou University,Zhengzhou,Henan Province,China2.The Brain Science Center,Beijing Institute of Basic Medical Sciences,Beijing,China3.School of Life Sciences,Zhengzhou University,Zhengzhou,Henan Province,China
摘要：Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg effect.Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions.The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system.Moreover,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease development.This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal perspectives for future research.
机标关键词：lactateneuroddegenerativediseasesmetabolism
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 69-74 )
英文信息