Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models
Poornima D.E.Weerasinghe-Mudiyanselage1
Joong-Sun Kim1
Taekyun Shin2
Changjong Moon1
1.Department of Veterinary Anatomy and Animal Behavior,College of Veterinary Medicine and BK21 FOUR program,Chonnam National University,Gwangju,Republic of Korea2.Department of Veterinary Anatomy,College of Veterinary Medicine and Veterinary Medical Research Institute,Jeju National University,Jeju,Republic of Korea
摘要：Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological disorder.In addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of non-motor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and pain.However,the pathogenesis and treatment of such non-motor symptoms in multiple sclerosis are still under research.Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune encephalomyelitis.Prior to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to characterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis.As such,no single animal model can mimic the entire spectrum of symptoms.This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms.Further,we highlighted gaps in the literature to explain the non-motor aspects of multiple sclerosis in experimental animal models,which will serve as the basis for future studies.
机标关键词：insightsspectrummodelsfromanimalmultiplenon-motorsclerosis
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 84-91 )
英文信息