Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease
Jianjian Chu1
Weicong Zhang2
Yan Liu3
Baofeng Gong1
Wenbo Ji1
Tong Yin1
Chao Gao1
Danqi Liangwen4
Mengqi Hao4
Cuimin Chen5
Jianhua Zhuang1
Jie Gao5
You Yin1
1.Department of Neurology,Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical University,Shanghai,China2.School of Pharmacy,University College London,London,UK3.Department of Clinical Pharmacy,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine4.Department of Neurology,Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical University,Shanghai,China;Clinical Pharmacy Innovation Institute,Shanghai Jiao Tong University School of Medicine,Shanghai,China5.School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai,China
摘要：The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease progression.Therefore,there is an urgent need for new effective drugs.The underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease treatment.Inhibiting inflammation can restore neuronal function,promote neuroregeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's disease.This review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's disease.The review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.
机标关键词：alzheimerstrategiesantibasedbiomaterialsdiseaseinflammatorytreatment
论文发表日期：2024-01-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 100-115 )
英文信息