Recent advances in the application of MXenes for neural tissue engineering and regeneration
Menghui Liao1
Qingyue Cui1
Yangnan Hu1
Jiayue Xing2
Danqi Wu2
Shasha Zheng2
Yu Zhao3
Yafeng Yu4
Jingwu Sun5
Renjie Chai6
1.State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing,Jiangsu Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China2.State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing,Jiangsu Province,China3.Department of Oto-Rhino-Laryngology,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China4.First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China5.Department of Otolaryngology-Head and Neck Surgery,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui Province,China6.State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing,Jiangsu Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China;Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan Province,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing,China;Beijing Key Laboratory of Neural Regeneration and Repair,Capital Medical University,Beijing,China
摘要：Transition metal carbides and nitrides(MXenes)are crystal nanomaterials with a number of surface functional groups such as fluorine,hydroxyl,and oxygen,which can be used as carriers for proteins and drugs.MXenes have excellent biocompatibility,electrical conductivity,surface hydrophilicity,mechanical properties and easy surface modification.However,at present,the stability of most MXenes needs to be improved,and more synthesis methods need to be explored.MXenes are good substrates for nerve cell regeneration and nerve reconstruction,which have broad application prospects in the repair of nervous system injury.Regarding the application of MXenes in neuroscience,mainly at the cellular level,the long-term in vivo biosafety and effects also need to be further explored.This review focuses on the progress of using MXenes in nerve regeneration over the last few years;discussing preparation of MXenes and their biocompatibility with different cells as well as the regulation by MXenes of nerve cell regeneration in two-dimensional and three-dimensional environments in vitro.MXenes have great potential in regulating the proliferation,differentiation,and maturation of nerve cells and in promoting regeneration and recovery after nerve injury.In addition,this review also presents the main challenges during optimization processes,such as the preparation of stable MXenes and long-term in vivo biosafety,and further discusses future directions in neural tissue engineering.
机标关键词：applicationengineeringregenerationmxenestissueadvancesneuralrecent
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 258-263 )
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