Role of lipids in the control of autophagy and primary cilium signaling in neurons
María Paz Hernández-Cáceres1
Daniela Pinto-Nuñez2
Patricia Rivera3
Paulina Burgos2
Francisco Díaz-Castro3
Alfredo Criollo4
Maria Jose Yañez2
Eugenia Morselli5
1.Instituto de Investigación en Ciencias Odontológicas(ICOD),Facultad de Odontología,Universidad de Chile,Santiago,Chile;Department of Basic Sciences,Faculty of Medicine and Science,Universidad San Sebastián,Santiago,Chile2.Department of Basic Sciences,Faculty of Medicine and Science,Universidad San Sebastián,Santiago,Chile3.Department of Basic Sciences,Faculty of Medicine and Science,Universidad San Sebastián,Santiago,Chile;Physiology Department,Faculty of Biological Sciences,Pontificia Universidad Católica de Chile,Santiago,Chile4.Instituto de Investigación en Ciencias Odontológicas(ICOD),Facultad de Odontología,Universidad de Chile,Santiago,Chile;Advanced Center for Chronic Diseases(ACCDiS),Facultad de Ciencias Químicas y Farmacéuticas & Facultad de Medicina,Universidad de Chile,Santiago,Chile;Autophagy Research Center,Santiago,Chile5.Department of Basic Sciences,Faculty of Medicine and Science,Universidad San Sebastián,Santiago,Chile;Autophagy Research Center,Santiago,Chile
摘要：The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human body.In neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely known.In this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons.Then we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.
机标关键词：controlroleautophagyciliumlipidsneuronsprimarysignaling
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 264-271 )
英文信息