Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance
Dina Medina-Vera1
Antonio Jesús López-Gambero2
Juan Antonio Navarro3
Carlos Sanjuan4
Elena Baixeras5
Juan Decara3
Fernando Rodríguez de Fonseca3
1.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND,UGC Salud Mental,Málaga,Spain;Facultad de Ciencias,Universidad de Málaga,Málaga,Spain;CIBER Enfermedades Cardiovasculares(CIBERCV),Hospital Universitario Virgen de la Victoria,UGC del Corazón,Málaga,Spain2.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND,UGC Salud Mental,Málaga,Spain;Facultad de Ciencias,Universidad de Málaga,Málaga,Spain;University of Bordeaux,INSERM,Neurocentre Magendie,Bordeaux,France3.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND,UGC Salud Mental,Málaga,Spain4.Euronutra S.L.Calle Johannes Kepler,Málaga,Spain5.Departamento de Bioquímica y Biología Molecular,Facultad de Medicina,Universidad de Málaga,Málaga,Spain
摘要：Alzheimer's disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer's disease.The pathogenesis of Alzheimer's disease is mainly mediated by the phosphorylation and aggregation of tau protein.Among the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug development.The present narrative review revises the interactions between these three elements:Alzheimer's disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.
机标关键词：phosphorylationinsightsinsulinbetweennovelperplinkerph
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 289-295 )
英文信息