The dorsal root ganglion as a target for neurorestoration in neuropathic pain
Guillermo Estivill-Torrús1
Ana Belen Martínez-Padilla2
Lourdes Sánchez-Salido1
Anne Baron-Van Evercooren3
Beatriz García-Díaz1
1.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONAND),Málaga,Spain;Unidad Clínica de Neurociencias,Hospital Regional Universitario de Málaga,Málaga,Spain2.Departamento de Biología Molecular y Bioquímica,Universidad de Málaga,Spain3.Sorbonne Université,Institut du Cerveau-Paris Brain Institute-ICM,INSERM,CNRS,AP-HP,Hôpital Pitié-Salpêtrière,Paris,France
摘要：Neuropathic pain is a severe and chronic condition widely found in the general population.The reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in patients.During the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical stimulation.Furthermore,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative therapies.Here,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic pain.More importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.
机标关键词：targetrootdorsalganglionneuropathicpainrestoration
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 296-301 )
英文信息