Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention
Yiyang Chen1
Wenxuan Tang2
Xinqi Huang2
Yumei An2
Jiawen Li2
Shengye Yuan2
Haiyan Shan3
Mingyang Zhang1
1.Institute of Forensic Sciences,Suzhou Medical College,Soochow University,Suzhou,Jiangsu Province,China;Shanghai Key Lab of Forensic Medicine,Key Lab of Forensic Science,Ministry of Justice(Academy of Forensic Science),Shanghai,China2.Institute of Forensic Sciences,Suzhou Medical College,Soochow University,Suzhou,Jiangsu Province,China3.Department of Obstetrics and Gynecology,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou,Jiangsu Province,China
摘要：Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae.However,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke subtypes.Recent studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral hemorrhage.Mitophagy,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged mitochondria.Mitophagy markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral hemorrhage.This review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral hemorrhage.In conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.
机标关键词：targethemorrhageinterventionintracerebralmitophagytherapeutic
论文发表日期：2024-02-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 316-323 )
英文信息