Small but big leaps towards neuroglycomics:exploring N-glycome in the brain to advance the understanding of brain development and function
Boyoung Lee1
Hyun Joo An2
1.Center for Cognition and Sociality,Institute for Basic Science(IBS),Daejeon,South Korea2.Asia-Pacific Glycomics Reference Site,Daejeon,South Korea;Graduate School of Analytical Science &Technology,Chungnam National University,Daejeon,South Korea
摘要：Glycosylation is a process that involves the addition of sugar moieties or glycans to different types of molecules,including proteins,lipids,and nucleic acids.Among these,protein glycosylation is one of the most prevalent forms of post-translational modification,playing a crucial role in biological complexity.With more than ten monosaccharides identified within mammalian brain cells and more than 1 × 1012 possible combinations,the heterogeneity of glycosylation is extensive(Conroy et al.,2021).The diversity of glycans and the complexity of their structures allow for a wide range of protein functions.N-glycans are one of the most abundant forms of glycans and are involved in various cellular functions.N-glycans can be added to proteins at specific sequons,Asn-X-Ser/Thr,and are classified into three main types in mature glycoproteins:high mannose,complex,and hybrid.High mannose N-glycans consist of 5-9 mannose residues linked to a chitobiose core and undergo processing into complex or hybrid forms in the Golgi apparatus(Varki et al.,2017).
机标关键词：developmentadvancefunctionsmallbrainexploringleapsn-glycome
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 489-490 )