Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination
Melissa Schepers
Tim Vanmierlo
Department of Neuroscience,Biomedical Research Institute,Faculty of Medicine and Life Sciences,Hasselt University,Hasselt,Belgium;Department of Psychiatry and Neuropsychology,School for Mental Health and Neuroscience,Maastricht University,Maastricht,Netherlands;University MS Center(UMSC)Hasselt-Pelt,Hasselt,Belgium
摘要：In neurodegenerative and classically demyelinating disorders such as multiple sclerosis(MS),spinal cord injury(SCI),stroke,and Charcot-Marie-Tooth disease,glial functioning is compromised and nervous tissue integrity is lost.Recently,primary neurodegenerative disorders such as Alzheimer's disease,amyotrophic lateral sclerosis(ALS),and Parkinson's disease(PD)are increasingly linked to impaired oligodendroglia functioning upon neurodegene ration.Due to the destructive micro-environment created by nervous tissue damage,the progressive cellular loss in these disorders,and the amitotic nature of neurons,spontaneous endogenous repair process are limited in nature.Hence,there is a medical need for efficient therapeutic strategies capable of supporting neuro-reparative processes to occur,likely supported by improved oligodendroglia cell functioning.
机标关键词：inhibitioninsightstargetnoveldiesiestphosesterase
论文发表日期：2024-03-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 493-494 )